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BACKGROUND: Related studies have confirmed that the experimental results and short-term clinical outcomes of artificial ligaments are satisfactory that the artificial ligaments can restore the stability of knee joint as soon as possible and ensure motor function. OBJECTIVE: To summarize the basic and clinical research progress of artificial ligaments. METHODS: The articles regarding artificial ligaments in repair of knee joint cruciate ligament injury were retrieved from Wanfang database, CNKI and PubMed database during 1985 to 2015 by computer. The keywords were “cruciate ligament injuries, artificial ligament, biological materials” in Chinese and English, respectively. RESULTS AND CONCLUSION: Compared with autologous and al ogenic ligaments, artificial ligament has good mechanical properties, and can get sufficient tensile strength and joint stability immediately after implantation, so as to ensure the cruciate ligament reconstruction of the knee joint. Artificial ligament technology has experienced carbon fiber ligament, polyester material and stent artificial ligaments. As a new type of polyester artificial ligament, LARS artificial ligament shows a good biocompatibility, on which, cel s can adhere, proliferate and differentiate wel . However, the controversies over the use of artificial ligament stil exist, and its long-term clinical effects stil need further observation. Further researches regarding the material selection, shape bionic design, weaving and surgical techniques of artificial ligaments are stil further needed.
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BACKGROUND: The use of tissue engineering technology to build a functional meniscus is a new idea for repair of meniscus injury. OBJECTIVE: To analyze the research progress of seed cells and scaffold materials in tissue-engineered meniscus repair. METHODS: A computer-based search of CNKI and PubMed was performed for articles related to tissue-engineered meniscus repair published from 1996 to 2015. The keywords were meniscal repair, meniscal injury, tissue engineering, tissue-engineered meniscus, biomaterials, stem cells in Chinese and English, respectively. RESULTS AND CONCLUSION: Tissue-engineered meniscus reconstruction is a more viable method for repair of meniscus injury. Mesenchymal stem cells are pluripotent cells that are ideal seed cells for tissue-engineered meniscus reconstruction. Scaffolds are one of important factors for meniscus repair, and natural meniscal scaffolds play an important role. Selection and development of scaffold materials for meniscus tissue engineering have experienced a rapid development period from a single material to composite materials. Composite materials make up a lot of shortcomings and deficiencies that a single material has, and open up new ideas for developing new materials. Meniscal tissues with geometric shapes can be constructed using tissue engineering technology. However, the long-term observation of the biological properties of meniscal tissues is necessary, and from basic to clinic, there is still a lack of reliable data to prove the effect of tissue engineering technology in the meniscus repair.
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Acrylamide(AA)is a chemical used in many industries around the world and more recently was found to form naturally in foods cooked at high temperatures.Acrylamide was shown to be a neurotoxicant,reproductive toxicant,and carcinogen in animal species.Only the neurotoxic effects were observed in humans and only at high levels of exposure in occupational settings. The present review is a synopsis of research on the genotoxicity and reproductive toxicant of acrylamide.
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Objective The differences of von Willebrand factor(vWF),hypersensitive C-reactive protein(hs-CRP) and soluble P-selectin CD62P were observed in coronary heart disease(CHD) patients with different syndrome patterns,and the correlation of traditional Chinese medical(TCM) syndrome patterns with endothelial damage,inflammation and platelet activation in CHD patients was investigated.Methods One hundred and eighty-six CHD patients were differentiated as the syndromes of blockage of heart-blood-stasis,phlegm blocking heart vessels,deficiency of heart and kidney yin,deficiency of both yin and Qi,and deficiency of yang and Qi.Thirty healthy volunteers served as normal control.The blood levels of vWF,hs-CRP and CD62P were detected in the CHD patients and the normal controls.Results Blood vWF level in CHD patients was higher than that in the normal controls(P0.05).Blood CD62P in the syndrome pattern of deficiency of yang and Qi was higher than the other patterns(P
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[Objective] To observe the therapeutic effect of Qianyang Dingxuan Decoction (QDD) for hypertension with yin deficiency and yang hyperactivity. QDD is mainly composed of Concha Haliotidis, Ostrea, Os Draconis, Concha Margaritifera Usta, Caulis et Folium Polygoni Multiflori, Radix paenonicae Alba, etc.. [Methods] Sixty cases (Group A) of essential hypertension were treated with QDD and 30 were in positive control group (Group B). Therapentic effect in the two groups were compared. [Results] The total effective rate was 93.3% in Group A and 76.7% in Group B, the difference being significant ( P 0.05). Effect of QDD in relieving symptoms was superior to Group B ( P